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It's pretty simple. First I sketch out my design on paper (which often involves browsing the Internet for ideas on how to portray a design, along with a lot of erasing). Then I apply a piece of Press'n Seal to the paper and trace the drawing using a ballpoint pen. Next I transfer the Press'n Seal to the onesie/shirt/tie/etc. I pick my colors, then stitch directly through the Press'n Seal. When the stitching is completed, I peel the Press'n Seal off. It sometimes sticks a bit in areas with small stitches, but a seam ripper or the back of a needle helps work it out.
These projects work up really quickly, especially after getting the design figured out. I also like them because they are easy to transport. I can work on them in the car, on the airplane, even at the beach. And bonus, the supplies aren't expensive. It just takes embroidery floss, a needle, a onesie, and a package of Press'n Seal (which you may already have in your kitchen).
A few disclaimers: I'm not sure how well these wash up (I always pre-wash and dry). Hand washing might help preserve the stitching, but who wants to hand wash a onesie? The final product would probably be more stable with some iron-on interfacing, but I don't like the stiffness. Also, this is by no means a product promotion for Press'n Seal. Finally, as you can probably tell, I am primarily working these designs in basic backstitch. I need to expand my stitch repertoire!
Thanks to Diane for letting me show off a little. I wish you all well from the sunshine state!